Some historians have suggested that the dual qualities of the snake — as both a symbol of healing and harm — stem from the nature of its venom, which can be both poisonous and curative. This paradoxical aspect aligns well with a ruler like Octavian, who was capable of delivering deadly strikes to his enemies and yet was eager to be perceived as a healer of the war-ravaged Roman world.

The Roman world embraced snake imagery, incorporating it into frescoes, mosaics, statues, and gold bracelets whose circular design evokes the ancient symbol of the Ouroboros — a serpent devouring its own tail. Derived from the Greek words oura (tail) and bora (eating), the Ouroboros is one of humanity's oldest symbols, embodying the cyclical nature of existence — seasonal changes, the rhythm of night and day, and the cycle of life and death.

Underlying these cycles is the concept of renewal, as reflected in the snake's periodic shedding of its own skin. In fact, in ancient Egypt, different types of snakes appeared in hieroglyphic writing and art, some carrying the meaning of rebirth and immortality.

Echoing the Egyptian theme of eternal life, the snake plays a significant role in The Epic of Gilgamesh, one of the oldest known works of literature, originating from ancient Mesopotamia around 2100 BC. In the story, Gilgamesh, the death-fearing protagonist, successfully retrieves the "Plant of Life" from the bottom of the sea, only to have it stolen and consumed by a serpent.

The loss, widely interpreted as symbolizing the inevitability of death, reinforces the epic's central theme: the wisdom gained through accepting life's limitations, and the importance of finding meaning within those limitations.